2010年12月4日 星期六

自體免疫檢查(凝血功能追因)

‧ANA (antinuclear atibody) FIA
抗細胞核抗體FIA法,用於診斷自體免疫疾病。
ANA>=160(X)suggestive of clinical significance,ANA測定為陽性,可合理懷疑患有疾病,如紅斑性狼瘡、類風濕性關節炎、進行性系統性硬化症、混合型結締組織病、傳染性單核細胞增多症、膽源性或膽汁性肝硬變、肝炎、瘧疾、白血病、自身免疫性溶血、重症肌無力等。經常用於判斷是否患有紅斑性狼瘡,檢測結果為陰性(小於等於1:160),可以排除患有紅斑狼瘡。

‧anti-phospholipid Ab-IgG
抗磷脂抗體 IgG,檢驗臨床意義包括Cardiolipin Ab、ACA、Lupus anticoagulant、LA、以及造成VDRL偽陽性的抗體,與栓塞、血小板減少、年輕婦女習慣性流產有關。
參考值APA-IgG (Antiphospholipid Ab-IgG type):小於15 GPLU/ml。

‧anti-phospholipid Ab-IgM
‧cardiolipin-IGG

‧ASMA (anti-sniitg muscle antibody serum)
抗平滑肌抗體。
與慢性活動性肝炎,自體免疫肝臟疾病,肝細胞腫瘤有關。ASMA對於狼瘡性肝炎,慢性活動性肝炎有很強的特異性,因為本抗體在SLE上不會被檢出之故,所以鑑別在臨床上診斷困難的狼瘡性肝炎非常有用。參考值Negative;(小於1:20X)。

‧DS-DNA

‧anti-mitochondria antibody (AMA) serum
Anti-mitochondrial antibodies (AMA) are autoantibodies, consisting of immunoglobulins formed against mitochondria,[1] primarily mitochondria in cells of the liver. The presence of AMAs in the blood or serum of a person is indicative of several autoimmune diseases such as primary biliary cirrhosis (PBC) (a scarring of liver tissue, confined primarily to the bile duct drainage system of the liver). It is present in about 95% of cases.
Primary biliary cirrhosis is seen primarily in middle-aged women, and in those afflicted with other autoimmune diseases. PBC is an autoimmune disorder, a condition in which the human body's immune defense system mistakenly attacks the body's own cells, or in this case parts of the cells.
Cause of AMAs is postulated that xenobiotic-induced and/or oxidative modification of mitochondrial autoantigens is a critical step leading to loss of tolerance. In acute liver failure AMA are found against all major liver antigens.

‧RF
類風溼因子過去常被誤認為等於類風溼關節炎(RA)實則錯誤。類風溼因子輕度偏高的病人,只有一半是類風溼性關節炎。反過來說,有25%的類風溼性關節炎,其中類風溼因子卻是正常的。RF 升高的意義在Low titer 時,代表慢性發炎或正常老化,在High titer時,通常是自體免疫疾病,如乾燥症候群(Sjogren's syndrome),RA,SLE 等。參考值0~20 IU/ml。
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自體免疫疾病的實驗室檢查
風濕病的實驗室診斷
抗磷脂抗體檢測及意義
抗磷脂抗體症候群Anti-phospholipid Syndrome (APS)

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